Changes made using tools such of the network scripts, though few things and then calls interface-specific scripts like ifup-ethXput down and then up so on. In Fedora, when you edit as nmcli do not require profile settings, then NetworkManager does change and has to be prompted to notice the change.
These commands require root privileges.
It is used for configurations with multiple IP addresses on an interface. Verifying the Boot Loader" Managing Log Files in a Graphical Environment" Mail Transport Protocols Expand section "
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